Several field experiments were conducted at BRRI farm, Gazipur in T. Aman (wet season) 2012, Boro (dry season) 2012-13 and Boro 2015-16 with urea alone or mixed with NEB a blend of natural root exudates. Intent of those trials was to evaluate the efficiency of NEB in saving of urea fertilizer for rice cultivation. Experimental design was randomized complete block (RCB) with three replications. Two experiments in T. Aman 2012, one in Boro 2012-13 were conducted with ten treatments comprising different combinations of urea and NEB. Different doses of urea (0, 50, 75 and 100% of recommended dose) were applied with and without NEB in Boro 2015-16. All plots received phosphorus (P), potassium (K) and sulphur (S) as blanket dose. Results of all experiments revealed that urea control treatment gave significantly lower grain and straw yield than all urea treated plots. But among the urea treated plots there were no significant yield difference between with NEB and without NEB. Effect of NEB on grain weight, filled grain and unfilled grain of Boro rice were insignificant. It is concluded that NEB was failed to save urea fertilizer for rice cultivation.