Kidney stone is a common problem in population and had medical or surgical treatment. Surgery treatment had many technique, but now, Percutaneous Nephrolithotomy (PCNL) is a standard surgery care of renal calculi. In recent years, surgeons defined modification methods of PCNL such as tubeless PCNL and totally tubeless PCNL. These modified methods were associated with less complication, reduced hospitalization and cost-effectiveness. The safety and efficacy of PCNL and tubeless PCNL in treatment of staghorn calculi were approve by researcher in recent years. The aim of this review is to evaluated the potential role of totally tubeless PCNL in treatment of staghorn calculi. Our finding was very low about this topic but show that totally tubeless PCNL potentially can be safe and effective for treatment patients with staghorn calculi. However, further studies with larger sample size are need to investigate the effectiveness of this technique in patients with staghorn calculi.