Appropriate fertilizer application is an important management practice to improve soil fertility and increase rice yield. An experiment was conducted for four consecutive seasons: Boro (dry season) 2011-12 to T. Aman (wet season) 2013 at the farmer’s field in Gongachara, Rangpur (25.86° N and 89.24° E) to find out optimum fertilizer dose for rice-based cropping systems in cold and submergence ecosystem in Bangladesh. In the present study, we examined the effects of eight fertilizer treatments and laid out in randomized complete block design with three replications. The treatment combinations were: T1=100% NPKSZn (Soil test basis), T2=T1+25% N, T3=T1+25% NP, T4=T1+25% NK, T5=T1+25% PK, T6=T1+25% NPK, T7=75% of T1 and T8=Absolute control. Results showed that application of different fertilizers significantly affected the rice yield at both of the seasons. In dry season 2011-12, the highest grain yield was found in treatment T3 while T6 gave the highest grain yield in dry season 2012-13. On the other hand, in wet season 2012 and 2013, the highest grain yield was found in T6 treatments. However, on the basis of yield performance, economic analysis and nutrient absorption, it is observed that 25% additional NP (T3) is more profitable than that of other fertilizers combinations.